Yes, I said it oral glutathione does not work. It is absolute garbage
Reasonably you’d think it would not – because oral glutathione is oxidized (makes it worthless right there) and then digested and broken down into all it’s components in stomach and gut.
So you know the problem with most people or kids (say with autism) is they cannot REDUCE Glutathione to GSH (from the oxidized called GSSG).
Don’t believe me?
Believe the researchers at a prestigious naturopathic research university in Washington state, Bastyr University.
Allen J, Bradley RD. Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteers. J Altern Complement Med. 2011 Sep;17(9):827-33. doi: 10.1089/acm.2010.0716.
Key points and quotes out of their study:
“The tripeptide glutathione (GSH) is the most abundant free radical scavenger synthesized endogenously in humans. Increasing mechanistic, clinical, and epidemiological evidence demonstrates that GSH status is significant in acute and chronic diseases. Despite ease of delivery, little controlled clinical research data exist evaluating the effects of oral GSH supplementation.”
The study itself:
Forty (40) adult volunteers without acute or chronic disease participated in this study.
Oral GSH supplementation (500 mg twice daily) was given to the volunteers for 4 weeks
The tools they used (lab studies):
“Primary outcome measures included change in creatinine-standardized, urinary F2-isoprostanes (F2-isoP) and urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG). Changes in erythrocyte GSH concentrations, including total reduced glutathione (GSH), oxidized glutathione (GSSG), and their ratio (GSH:GSSG) were also measured by tandem liquid chromatography/mass spectrometry”
There were no differences in oxidative stress biomarkers between treatment groups at baseline. Thirty-nine (39) participants completed the study per protocol. Changes in creatinine standardized F2-isoP (ng/mg creatinine) (0.0±0.1 versus 0.0±0.1, p=0.38) and 8-OHdG (μg/g creatinine) (-0.2±3.3 versus 1.0±3.2, p=0.27) were nonsignificant between groups at week 4. Total reduced, oxidized, and ratio measures of GSH status were also unchanged.
No significant changes were observed in biomarkers of oxidative stress, including glutathione status, in this clinical trial of oral glutathione supplementation in healthy adults.
Remember this when you pick a glutathione — it should be GSH (reduced), stable, protected by either a liposomal or complexed into another structure (such as a NANO structure), absorbable, and show elevated blood level studies (efficacious), ad have a patent – because this would be an incredibly valuable product. I know because I am involved or own the patents on two of these. Comments on this are appreciated.
We are currently going through FDA approval studies (it’s GRAS-E so it could be sold as a vitamin) so we can prove efficacy in a a certain anti-viral disease.