Life Extension® Neuro-Mag® (Magnesium L-Threonate) Product Review

My patient population is aging and concerned about memory loss. They are in a constant state of wonder about how to prevent those issues, and I have recently found an answer. Magnesium L-Threonate. It crosses the blood brain barrier and improves memory in a natural way. Magnesium L-Threonate is available today for everyone, young and old, who wants to be sharp, clear, and focused. I was looking into research on magnesium and the brain, when I ran into the MIT study published in 2010 showing Magnesium L-Threonate is the only form of magnesium to cross the blood-brain barrier and show observable improvements in cognitive measures.*

However, please kindly note that at the moment there simply lacks substantiated evidence demonstrating whether or not Magnesium L-Threonate is in fact superior to other Magnesium compounds. If further studies are conducted and conclusively demonstrate that Magnesium L-Threonate is indeed superior in any respect, then I will most certainly adjust my perspective on the compound accordingly.


Magnesium L-Threonate is a unique form of magnesium. Magnesium L-threonate is simply a form of magnesium ions chelated to a fairly simple organic molecule, threonine, a metabolite of vitamin C. Magnesium L-Threonate is not a stool-softener and does not act as a laxative. Plus, Magnesium L-Threonate is free from any genetically engineered (GE) ingredients and is non-GMO. Magnesium L-Threonate has a great uptake into the brain and has increased cognitive effects compared to more common forms of magnesium supplements like magnesium citrate. Magnesium L-Threonate is one of the three forms of magnesium chelates in Natural Stacks highly effective nootropic supplement. The results, published in 2010 in the very prestigious journal, Neuron, clearly show that only Magnesium L-Threonate is able to increase brain magnesium levels.*

Magnesium L-Threonate is a new form of this element, which is derived from L-Threonic acid. Overall, the MagTech with Magnesium L-Threonate is a high quality optimal magnesium complex. The primary benefit of Magnesium L-Threonate is an improvement in memory. Magnesium L-Threonate is for enhanced cognitive function so, in the nootropic world, Magnesium L-Threonate is considered one of the essential components due to its influence and maintenance of proper nerve and muscle functions as well as the metabolism of glucose for energy.

A popular supplement that may be stacked with Magnesium L-Threonate is Calcium. Magnesium L-Threonate is the only form of magnesium proven in animal studies to cross the blood-brain barrier. Since Magnesium L-Threonate is naturally calming you might notice it can cause relaxation but this depends on the amount taken. Magnesium Glycinate is a very good choice for muscle cramps and “charlie horses”, but some of us may find that Magnesium L-Threonate is the best choice for brain “muscle” health.

I suggest trying Neuro-Mag® from Life Extension® as the best option for this form of magnesium and to improve brain health. There will be more articles to come on brain health.


  1. *Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010 Jan 28;65(2):165-77.
  2. *Slutsky I, Abumaria N, Wu LJ, et al. Enhancement of learning and memory by elevating brain magnesium. Neuron. 2010 Jan 28;65(2):165-77.