The Purser Protocol for MTHFR
How MTHFR Causes Chronic Inflammation (and How We Treat It)
MTHFR mutations can elevate homocysteine, disrupt methylation, and trigger cytokine-driven inflammation. This creates a cycle of fatigue, pain, and hormonal imbalance. The Purser Method® identifies the exact biochemical blocks and uses targeted nutrients to restore methylation and calm inflammation.
Dr. Purser is a nationally recognized MTHFR doctor specializing in advanced MTHFR treatment for patients struggling with fatigue, pain, anxiety, and chronic inflammation. Many patients with MTHFR variants experience hidden methylation breakdown and MTHFR inflammation that traditional medicine overlooks.
Exhausted beyond belief?
Anxiety that never ends?
Depression you cannot pull out of?
These are the most common symptoms of MTHFR - the genetic transcription error that MILLIONS suffer from.
Most doctors and practitioners haven’t taken the time to understand the complexities of MTHFR. The symptoms, oftentimes debilitate its victims, are only masked with pain meds, anti anxiety meds, and supplements that do more harm than good.
Are you frustrated that your symptoms have never fully been addressed?
The answer to these frustrations is locked within your cells. With the right tools and guidance, you WILL conquer MTHFR and live a full and happy life.
Taking your life back from MTHFR can be accomplished with 3 simple steps:
Identify what variant of MTHFR you have (the root of the illness)
Discover what Intracellular Nutrient Deficiencies are caused by your variant
Supplement with the correct versions of nutrients that YOUR body needs (everyone is unique)
What is causing your symptoms?
MTHFR is a genetic illness that affects the body’s ability to methylate, or process, certain vitamins and carbohydrates. In simpler terms, it's a problem with the body’s ability to convert carbohydrates into ATP, the primary energy source for our cells.
Every human being relies on ATP to carry out all the functions within our cells. Remember, the mitochondria is the powerhouse of the cell, but what is it making to power everything? ATP.
In a healthy individual, one carbohydrate molecule is converted into 32 ATP molecules utilizing the process of the Krebs or Citric Acid Cycle.
However, for those with MTHFR, the conversion is MUCH less efficient. Depending on the specific genetic mutation or combination of mutations, those with MTHFR can only produce between 9-23 ATP molecules from one carbohydrate molecule. They have dealt with this their ENTIRE life. Trying to catch up on energy for years leads to chronic illnesses and symptoms.
Symptoms of MTHFR
The most common symptom of MTHFR is Chronic Fatigue. Since ATP is crucial for energy, those with MTHFR often feel perpetually tired or as if they’re always lagging behind. This is because their bodies cannot produce ATP at the same rate as those without the mutation.
There are several intracellular deficiencies that demonstrate the intensity of MTHFR disorders.
B vitamins, when low, lead to low testosterone and hypothyroidism. The body’s inability to properly process these vitamins means that if you have MTHFR, you can’t produce adequate amounts of essential hormones, making their symptoms even worse.
Step 1: How to test for MTHFR
The following are the best options for MTHFR Genetic detection:
The Works Genetic Test - designed to look at the key SNPs (genetic code bits that have been changed due to MTHFR) related to methylation and energy production.
23andMe or Ancestry - Common genetic testing that offers insight into ancestry lines and genetic variants. Each has an add on option for health insights, and with this you request the Raw Data. Run that through Nutra Hacker to get imputed genetic results.
With these results, you’ll know what variants of MTHFR you may have. The most common are the C677T and A2198C but some may have homozygous, heterozygous, compound heterozygous versions of these. Each version means a different effectiveness of energy production.
This custom-made genetic test, designed by Dr. Purser, dives deep into the key genetic factors he believes contribute to the biggest health challenges. With The Works!, you’ll gain powerful insights into your nutrition, fitness, and overall physiology, all in one comprehensive analysis.
Your personalized report will cover:
✔️ Methylation & DNA Repair – MTHFR and other genetic markers influencing wellness
✔️ Stress & Resilience – Fight-or-flight response and how your body handles stress
✔️ Detox & Antioxidants – Glutathione levels, toxin elimination, and free radical defense
✔️ Inflammation & Recovery – How your body reacts to inflammation and repairs cells
✔️ Brain Chemistry & Energy – Neurotransmitter balance, overall energy production, and metabolism
✔️ Weight, Nutrition & Cardiovascular Health – Blood sugar levels, vitamin deficiencies, fat metabolism, and exercise response
What’s Included
🩺 30-Minute Consultation with Dr. Purser – Get expert insights and a breakdown of your results
💊 Custom Supplement Guide – Receive tailored recommendations with direct links to purchase
Take charge of your health with data-driven guidance! Order now for personalized, science-backed wellness strategies.
Step 2 - Intracellular Testing
CMA Intracellular Micronutrient Testing - these assays look at 48-100 vitamins, minerals, amino acids, and antioxidant activity inside your cells. This is the best place to start as MTHFR causes intracellular deficiencies. Treat these deficiencies and all turns around.
A side note: Our Intracellular Micronutrient Testing comes bundled with a 30 Minute Consult with Dr. Purser.
YOUR FAST‑TRACK TO DEEP, CELLULAR‑LEVEL HEALTH
Unlock the test our clinic trusts most for identifying the hidden nutrient deficiencies that drain your energy, slow your metabolism, and impact long‑term wellness. This exclusive bundle includes a personal consultation with one of our highly trained wellness staff, giving you expert interpretation and a personalized plan based on your results.
The CMA goes far beyond standard bloodwork. Instead of measuring nutrients floating in your bloodstream, it analyzes what’s happening inside your immune cells—where real metabolic activity takes place. This gives you a true, long‑term picture of your nutrient status, oxidative stress, and cellular resilience.
WHY THE CMA MATTERS
✔️ Identifies Hidden Deficiencies — Vitamins, minerals, amino acids, and more
✔️ Reveals Oxidative Stress Load — Understand how toxins, medications, and daily exposures impact your cells
✔️ Shows True Metabolic Function — How efficiently your cells produce energy
✔️ Provides Long‑Term Insight — Beyond the “snapshot” of standard serum tests
This is the test for people who want answers, clarity, and a targeted plan—not guesswork.
WHO BENEFITS MOST
Anyone wanting a personalized nutrition & supplement strategy
Women navigating fertility, pregnancy, perimenopause, or menopause
Individuals with fatigue, mood swings, low vitality, or chronic stress
High performers, athletes, and those under heavy physical or emotional load
People preparing for or recovering from surgery
Those managing weight, metabolic syndrome, or chronic conditions
Anyone who feels “off” despite normal labs
If you’ve been searching for the root cause of your symptoms, this test brings clarity.
WHAT’S INCLUDED
🩺 30‑Minute Consultation with Our Wellness Staff Your results, explained clearly—with actionable next steps.
💊 Customized Supplement & Nutrition Plan Tailored recommendations based on your cellular needs, with direct links for easy ordering.
Your kit includes everything needed for your blood draw. You’ll simply schedule your draw with a qualified provider (fees vary). We typically recommend AnyLabTestNow, and you can easily find a location near you at: www.anylabtestnow.com/locations
Once your sample is collected, reach out to our office and we’ll book your results appointment.
YOUR HEALTH DESERVES MORE THAN GUESSING
Get the data, the clarity, and the expert guidance you need to finally move forward. Order your CMA bundle today and take the first step toward deeper, long‑lasting wellness.
OUR MOST COMPREHENSIVE CELLULAR HEALTH TEST
Experience the deepest look into your nutrient status, antioxidant capacity, and cellular resilience with this upgraded bundle—complete with a personal consultation with one of our highly trained wellness staff.
This enhanced package combines the Cellular Micronutrient Assay (CMA) with the REDOX Panel, adding 50 additional antioxidant‑focused nutrient markers that reveal how well your cells defend, repair, and recover from oxidative stress.
If you want the most complete picture of your metabolic health, this is the test.
WHY THIS TEST IS DIFFERENT
The CMA measures nutrient levels inside your immune cells—not just in your bloodstream—giving you a long‑term, accurate view of your metabolic and nutritional status.
The REDOX Panel expands this even further by analyzing 50 additional antioxidant‑related nutrients, helping you understand:
✔️ How well your cells neutralize free radicals
✔️ Your antioxidant reserves and recovery capacity
✔️ How toxins, medications, pollution, and stress impact your cellular health
✔️ Your vulnerability to oxidative damage and inflammation
Together, these tests provide the most complete cellular health assessment available.
WHAT THIS COMPREHENSIVE PANEL REVEALS
✔️ Micronutrient Levels — Vitamins, minerals, amino acids, and essential cofactors
✔️ Antioxidant Status (REDOX) — 50 additional markers tied to cellular defense and repair
✔️ Oxidative Stress Load — How environmental and lifestyle exposures affect your cells
✔️ Metabolic Efficiency — How well your cells produce energy
✔️ Long‑Term Nutrient Patterns — Beyond the “snapshot” of standard serum tests
This is the test for people who want answers—not assumptions.
WHO BENEFITS MOST
Anyone wanting a personalized, data‑driven supplement and nutrition plan
Women navigating fertility, pregnancy, perimenopause, or menopause
Individuals with fatigue, mood swings, low vitality, or chronic stress
High performers, athletes, and those under heavy physical or emotional load
People preparing for or recovering from surgery
Those managing weight, metabolic syndrome, or chronic conditions
Anyone who feels “off” despite normal labs
If you’ve been searching for the root cause of your symptoms, this test brings clarity.
WHAT’S INCLUDED
🩺 30‑Minute Consultation with Our Wellness Staff A personalized review of your results with expert interpretation and next‑step guidance.
💊 Customized Supplement & Nutrition Plan Tailored recommendations based on your cellular and antioxidant needs, with direct links for easy ordering.
Your kit includes everything needed for your blood draw. Patients are responsible for arranging their own draw with a qualified provider (fees vary). We typically recommend AnyLabTestNow, and you can find a location near you at: www.anylabtestnow.com/locations
Once your sample is collected, contact our office and we’ll schedule your results appointment.
THE MOST COMPLETE VIEW OF YOUR CELLULAR HEALTH
Stop guessing. Start measuring. This combined CMA + REDOX panel gives you the data, direction, and expert support you need to transform your health from the inside out.
Order your upgraded bundle today and take control of your long‑term wellness.
Step 3 - Personalized Nutrition Guidance
With results from these tests a personalized supplementation regimen is designed to fit your genetic makeup and current deficiencies.
Intracellular testing comes with a consultation where Dr. Purser will walk through your current cellular micronutrient levels and provide a guide to how best treat the deficiencies found in your results. Some will be supplements and others will be foods to incorporate or avoid in your day to day. Each one of us is unique so a personalized, hands on approach is the only way to properly manage MTHFR.
98% of our patients have drastic recoveries from their MTHFR symptoms. You will too.
Treatment for MTHFR
MTHFR as a genetic condition cannot be “cured” but there is HOPE. Your best option is to go to the Root of the issue and develop a treatment plan around it.
What is the Root of MTHFR?
At its very base, MTHFR affects the effectiveness of cellular mechanisms of energy production. The methylation cycle is thrown off and the only way to fix or bypass the broken spots is to supplement with key nutrients. These supplements are specially designed to fit the “slots” where the body struggles to process or methylate vitamins.
Think of it as a brick wall missing bricks. The supplements act as the missing bricks, filling in the gaps and ensuring the wall (the body’s metabolic processes) remains stable and functional.
The most common deficiencies observed across MTHFR patients listed below.
Most common intracellular vitamin and mineral deficiencies caused by MTHFR:
Vitamin B6 (Pyridoxine)
Folate (5-MTHF)
Vitamin B12 (Mehtylcobalamin, Adenosylcobalamin, Hydroxycobalamin)
Vitamin B5 (Pantothenic Acid)
Choline
Zinc (Zinc Glycinate, Zinc Picolinate)
N-Acetyl Cysteine (NAC)
Tyrosine
Serine
Glutathione (GSH Reduced Glutathione)
All of these can be found in Physician Designed Supplements
MTHFR Daily- Support for the long run, to be used to manage methylation over time
VARS Glutathione - Master antioxidant for detox and energy production
Information on Overmethylation.
The 85% Solution by Dan Purser MD - Amazon #1 Best Seller
The top selling book on MTHFR and Methylation for 2 years on Amazon and Kindle.
What can I expect?
Imagine waking up each morning with a renewed zest for life, feeling energized and ready to take on the world. By mastering your methylation and addressing underlying intracellular deficiencies, you’re not just improving your health - you’re transforming your life.
With our MTHFR treatments, you’re on the path to creating more cellular energy than ever before. Gone are the days of feeling perpetually drained, struggling to get through the day, or missing out on life’s beautiful moments due to fatigue. Instead, you’ll find yourself with an abundance of energy, clarity of mind, and a newfound enthusiasm for life’s adventures.
As you embark on this journey of healing and rejuvenation, remember that mastering methylation is more than just a treatment; it’s a gateway to a life full of potential, passion, and purpose. With our guidance and your commitment, you’ll not only address the challenges of MTHFR but also unlock a version of yourself that’s vibrant, thriving, and truly alive.
So, are you ready to live a full life, unburdened by the limitations of the past? Embrace the future with optimism and confidence, knowing that the BEST version of you is just around the corner. Let’s embark on this transformative journey together and witness the remarkable change that awaits.
We are here to help!
Every step of the way, Dr. Purser and his trained staff are here to provide guidance and support in CONQUERING your MTHFR.
The first step of the rest of your life starts now.
Clinic: 801-796-7667 or info@danpursermd.com