High homocysteine signals a broken transsulfuration pathway, leaving you unable to detox or convert it into glutathione. This shows up in conditions like PCOS and fibromyalgia, where patients often struggle with inflammation, pain, and even infertility. Genetics play a big role—there are 17 SNPs that can lock homocysteine in place—but vitamin deficiencies can make it worse. The real breakthrough isn’t lowering homocysteine itself but calming the cytokines it triggers, like IL-8 and MCP-1. That’s why VARS Glutathione, the only patented oral form proven to work, is so powerful—it lowers those cytokines back to normal and helps the body detox effectively.
What is MTHFR? What can YOU do about it?
MTHFR is one of the most studied genetic SNPs, with the two main variants being C677T and A1298C. These changes reduce the body’s ability to process folate and make energy, leaving people exhausted and deficient in key nutrients. Specialized folates, B12 forms, and glutathione can bypass the blockages, and products like MTHFR Daily were designed specifically to fill these nutrient gaps so patients can restore energy and thrive.
What is Intracellular Testing?
Intracellular testing, or the CMA Cellular Micronutrient Assay, measures over 100 vitamins, minerals, amino acids, and antioxidants inside your cells—not just in your blood. Unlike serum tests, which show short-term levels, intracellular testing reveals what your cells have been missing over the last 100 days. Low levels can mean weak enzymes, non-functioning proteins, and accelerated aging. By identifying deficiencies and matching them with the correct nutrient forms for your genetics, you can target fatigue, anxiety, depression, and other chronic issues at the root. Get your CMA by calling our office at 801-796-7667.
How To Know If You Have High Homocysteine?
High homocysteine often shows up first as widespread inflammation—pain all over, poor circulation, or even early warning signs of cardiovascular problems like stroke and heart attack. The best way to know for sure is through testing: a blood test can measure homocysteine directly, while a CMA with Redox uncovers the vitamin deficiencies driving it. For genetic causes, the DRP Genetics panel screens 15–16 of the 17 known SNPs that can cause permanently high homocysteine. If your levels are fixed by genetics, reduced glutathione and targeted B vitamins (like MTHFR Daily) are key to balancing the cytokines and deficiencies that come with it.
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Dr. Purser explains how certain environmental chemicals can trigger major inflammatory events in infants and young children—events that may contribute to autism in some cases.
Glutathione and Your Ability To Detox?
Your body’s ability to detox depends on one critical pathway—turning homocysteine into glutathione. But for millions with MTHFR or other genetic SNPs, this process is broken, leaving them vulnerable to toxins, inflammation, and cytokine storms. That’s why VARS Glutathione is such a breakthrough: it’s reduced, functional, and proven to lower harmful cytokines like IL-8 and MCP-1, giving your body the detox power it needs. After 15 years of research and real patient results, it’s the only oral glutathione that actually works where it matters—inside your cells.
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What I see again and again is an inability to detox caused by failures in the Transsulfuration Pathway. This is your pathway that converts homocysteine to glutathione. If you have MTHFR or 16 other Gene SNPs, you will have problems with this pathway.
What Happens If You Have A Gene SNP?
Genetic SNPs are tiny changes in your DNA that can drastically affect how well your enzymes and proteins work. For example, being homozygous for MTHFR C677T leaves that enzyme functioning at only about 30% efficiency, which can drain your energy and impair folate processing. Similarly, errors in SOD genes reduce your body’s ability to neutralize free radicals. While we can’t change your genes, we can work around them by identifying these weaknesses and filling the gaps with targeted nutrition and supplementation—helping your body function closer to its full potential.
What is the BEST Genetic Test To Get??
Not all genetic tests are created equal. Many only scratch the surface, while the best panels look at hundreds of SNPs that impact methylation, detox, hormones, and nutrient absorption. For real results, you need a test that’s private, comprehensive, and clinically useful—like the ones we recommend in practice that help guide targeted treatment plans.
Gene Types Explained
Your genetic results might list “wild type,” “heterozygous,” or “homozygous,” but what does that mean? Wild type means both copies of your gene are normal, heterozygous means one is normal and one has a change, and homozygous means both copies have the same change. With genes like MTHFR, these variations can affect how efficiently your body processes nutrients like folate—sometimes cutting function by 40–70%—which is why targeted nutrition and testing matter.
What Makes A Functional Glutathione?
Most glutathione supplements fail because they break down before your body can use them. VARS Glutathione is different—it’s patented, validated, and proven to raise real intracellular glutathione levels. That means it actually works to calm inflammation, lower cytokines, and protect your cells where it matters most.
The Real Problem With CT Scans?
While CT scans are sometimes necessary, the radiation exposure they create can cause oxidative damage in the body. That’s why antioxidants like glutathione are so important—when taken in a validated, reduced form, they help detox and protect against the harmful effects of scans, heavy metals, and chemicals like gadolinium. Dr. Purser’s VARS Glutathione and Nayan Patel’s topical Glutaryl formulas are the only patented, validated glutathiones proven to actually work at this level, helping patients recover quickly from oxidative stress.
Be Wary Of Glutathione Product Claims!
Many skincare and supplement companies throw around the word “glutathione,” but most of their products don’t actually deliver meaningful amounts—or the right form. For example, a popular serum claims anywhere from 50,000 ppm to just 500 ppm glutathione, which would equal almost nothing per bottle. On top of that, most products use oxidized glutathione, which doesn’t work in the body. That’s what makes VARS Glutathione different—it stays in its reduced, functional form all the way until your cells use it, giving you a real therapeutic dose that actually works.
DRP Genetics Testing Update
The new DRP Genetics test, designed by Dr. Purser in collaboration with MaxGen, makes genetic testing simple and precise. Each kit comes pre-filled with everything you need—just swab your cheek, place it in the vial, and send it back the same day using the prepaid mailer. This curated panel focuses on key SNPs Dr. Purser selected after years of research, giving patients clearer answers and actionable insights into their health.
🧬 What’s more powerful than glutathione or vitamin C?
Superoxide dismutase (SOD)—your body’s first line of defense against DNA-damaging free radicals. SOD neutralizes superoxide radicals at the source of cellular energy production. But as we age—or if we have genetic SNPs—our ability to make SOD drops. That’s why we created VARS SOD, with over 10,000 IU per dose (most products have less than 240 IU). It’s a game changer for anti-aging, DNA protection, and reducing inflammation at the root.
EBV and Fibromyalgia Related??
Just because you have EBV antibodies doesn’t mean it’s active—it usually means you’ve built immunity. The real issue? Most fibromyalgia patients have low reduced glutathione, which viruses like EBV intentionally suppress. That’s why symptoms overlap: fatigue, pain, immune dysfunction. Fix the glutathione issue, and you can support recovery on a deeper level.
Treat Root Cause Symptoms?
Tired, foggy, low hormones, and nothing helps? It’s probably not magic—it’s nutrient deficiency. Dr. Purser uses CMA with Redox testing to go deeper than your average doctor ever will. He sees severe lipoic acid, biotin, PQQ, and lithium deficiencies causing symptoms that mimic dementia, thyroid issues, or low testosterone. It’s not “manopause”—it’s vitaminopause. Find the root cause, don’t just chase prescriptions.
The Struggle of Homocysteine
High homocysteine? It’s not the number—it’s the cytokines it triggers (like IL-8) that cause strokes, kidney failure & inflammation. We found 17 gene SNPs + 12 vitamin deficiencies that drive it—and VARS Glutathione helps shut it down.
PEMT and connection to choline and glutathione!
One of the most powerful nutrients you’ve never heard of? Phosphatidylcholine. It builds the walls of your cells, protects your gut lining, supports nerve function, and even helps your body make bile. If you have a PEMT gene mutation, your body struggles to make it—and that means gut issues, nerve dysfunction, and chronic inflammation.
Have Fibromyalgia? This video is for you - let’s get to the root.
The real root of fibromyalgia? It’s not just pain — it’s copper. We’ve uncovered that fibromyalgia is often driven by genetic mutations (like CBS, GAD1, GAD2) that affect how your body handles copper. The copper builds up in your blood but never makes it into your cells — leading to widespread pain, inflammation, and migraines.