HEALTH BLOG

And Other Writings by Dan Purser MD

Jackson Larkin 5/12/21 Jackson Larkin 5/12/21

Why do I need methylated B Vitamins?

Many vitamins and minerals go through the methylation cycle meaning a methyl group is added to a molecule to turn it into its active form. Individuals with MTHFR and other genetic methylation errors are unable to efficiently create the methylated versions of those certain vitamins and minerals. Those with MTHFR specifically cannot make enough 5-MTHF, an activated form of folate, which in turn prohibits the ability to methylate other vitamins.

These errors can lead to a number of cellular deficiencies which can cause chronic fatigue, anxiety, depression (BASICALLY MAKE YOU FEEL LIKE A SLUG) and many other common health issues.

Supplementing with the correct forms, these methylated forms, of B Vitamins assists your cells in their work to create energy which in turn powers you!

Learning to deal with your methylation issues, and treating them correctly, can make a huge difference in your overall health and well-being.

DON'T CONTINUE TO SUFFER NEEDLESSLY, start making the change today!

PhysicianDesigned.com MTHFR supporting products are a great place to start. Understand the genetics behind methylation with a Pro7 Genetic test, and get a snapshot of your current vitamin and mineral deficiencies with a Spectracell Intracellular test.

You can feel great! What are you waiting for?

Dan Purser MD 2/28/18 Dan Purser MD 2/28/18

New Products Coming!

New products coming to the Physician Designed line.

Just Some HUGE ANNOUNCEMENTS!

Four NEW or super IMPROVED PRODUCTS!

Our incredible improved all natural VARS MINT BURST LIPOSOMAL GLUTATHIONE — works great and tastes AMAZING! Available this week...

Our new MTHFR SUPPORT PLUS is almost (nothing’s perfect— right?) for A1298C MTHFR or Compound Heterozygous MTHFR. This contains FOLINIC ACID and not the Quatrafolate that the C677T errors need. Great stuff. Try the PLUS with the MTHFR SUPPORT.

MTHFR SUPPORT is available now from us with our Physician Designed label (me). Try it if you have MTHFR — BEST BASE product out there for MTHFR especially the C677T error. Super good (but start low go slow).

More METALLOTHIONEIN SUPPORT for those who suffer from metal toxicity or fibromyalgia. Supports your copper levels (and other metals) and makes them normal. Don’t believe? Try it — again start low and go slow but build up to 4-5 a day and see what happens. Ask others who take it.

Dan Purser MD 2/27/18 Dan Purser MD 2/27/18

GENOVA™ Neopterin Biopterin Urine Profile for MTHFR

Excessive Neopterin NEGATIVELY impacts the Nitric Oxide pathway in the body

This test result is bad and could indicate an infection, especially viral.

This is a great test for those with A1298C and especially who are Homozygous A1298C. Neopterin is bad while biopterin is good. If neopterin is repeatedly high, the BH4 is low.

Neopterin is a sensitive marker of cellular mediated immunity. Reduced levels reflect cellular immunity weakening.

Increased neopterin occur with infectious, inflammatory, immune system dysfunction or neoplastic disease evolution.

Excessive neopterin negatively impacts the Nitric Oxide pathway in the body (e.g. excessive peroxynitrite formation and oxidative stress). Neopterin is a useful index of inflammation response associated with immune system activation.

Tetrahydrobiopterin (BH4) is the cellular protection or antidote to neopterin. It helps to alleviate the oxidative damage caused by neopterin induced immune activation. When BH4 is oxidized by neopterin, it forms biopterin.

If neopterin is constantly increased, then there is a possibility that BH4 levels are inadequate.

“The extent of differential between these two pterins could be considered to be an index of deleterious consequences of cellular inflammation. Decreased biopterin relative to neopterin might suggest inadequate antidote protection capability and increased oxidative damage caused by immune activation (in addition to the original cause of the immune system activation). Too much Oxidized Biopterin (Box) relative to BH4 might suggest an inability to recycle the Box back to BH4 and also inadequate total biopterin to deal with the amount of neopterin.”

This would mean the person needs BH4 (Kuvan™ or TetraHyrdoBiopterin) to reduce the neopterin levels. I usually start this at 2.5 mg daily, then slowly go up. BH4 can significantly improve mood and help with depression, anxiety, and insomnia for these patients.