GENOVA™ Neopterin Biopterin Urine Profile for MTHFR

Feb 27

This test result is bad and could indicate an infection, especially viral.

This is a great test for those with A1298C and especially who are Homozygous A1298C. Neopterin is bad while biopterin is good. If neopterin is repeatedly high, the BH4 is low.

Neopterin is a sensitive marker of cellular mediated immunity. Reduced levels reflect cellular immunity weakening.

Increased neopterin occur with infectious, inflammatory, immune system dysfunction or neoplastic disease evolution.

Excessive neopterin negatively impacts the Nitric Oxide pathway in the body (e.g. excessive peroxynitrite formation and oxidative stress). Neopterin is a useful index of inflammation response associated with immune system activation.

Tetrahydrobiopterin (BH4) is the cellular protection or antidote to neopterin. It helps to alleviate the oxidative damage caused by neopterin induced immune activation. When BH4 is oxidized by neopterin, it forms biopterin.

If neopterin is constantly increased, then there is a possibility that BH4 levels are inadequate.

“The extent of differential between these two pterins could be considered to be an index of deleterious consequences of cellular inflammation. Decreased biopterin relative to neopterin might suggest inadequate antidote protection capability and increased oxidative damage caused by immune activation (in addition to the original cause of the immune system activation). Too much Oxidized Biopterin (Box) relative to BH4 might suggest an inability to recycle the Box back to BH4 and also inadequate total biopterin to deal with the amount of neopterin.”

This would mean the person needs BH4 (Kuvan™ or TetraHyrdoBiopterin) to reduce the neopterin levels. I usually start this at 2.5 mg daily, then slowly go up. BH4 can significantly improve mood and help with depression, anxiety, and insomnia for these patients.

genova urine profilegenovamthfrmthfr test resultsdan purser md mthfrpurser mthfr

Dan Purser MD

Dr. Purser was from the graduating class of 1981, Brigham Young University. Dr. Purser graduated from “Old Miss” (the University of Mississippi, School of Medicine) where he completed medical school near the top of his class.

Dr. Purser began with a practice in family medicine with an emphasis on geriatrics during the 1980’s. In the late 1990’s, coupled with his prior education and vast experience with aging patients, Dr. Purser continued with in depth medical studies and interests in neurological studies, with an emphasis in pituitary dysfunction, as well as intensive preventive care of the body, and how these inter-relate. With Dr. Purser’s vastly accumulated experience, he’s enjoyed tremendous success with his patients in both his preventive medicine and traumatic brain injury practices since the late 1990’s. Currently his “day job” involves work in a plastic surgery group where he deals with complex wound healing issues. He also consults for, and designs products that you can feel working for a number of nutraceutical companies.

These intense studies and long standing experience in the medical profession have led Dr. Purser to be a very unique contributor to an outstanding textbook for physicians “Program 120: A Physician’s Handbook on Proactive Preventive Medicine”. This text is used as his curriculum in educating fellow physicians throughout the United States and abroad. Dr. Purser’s current writings include a book directly addressing the pituitary endocrinology issues of Fibromyalgia. Dr. Purser is a long standing Utah Medical Association delegate with honors, certificates and outstanding achievements from the American Medical Association and has been the Utah County representative for physicians practicing there to the Utah Medical Association the last several years. Also Dr. Purser is involved in ongoing research in cardiology, pituitary endocrinology, and pharmacology with a team in the Los Angeles area.

http://danpursermd.com

GENOVA™ Neopterin Biopterin Urine Profile for MTHFR

GMO vs non-GMO