Dr. Purser’s Background, Credentials & Reviews

1. You’re ranked as the top MD in the USA — is that due to your work with hormones?

While my ranking is heavily influenced by my success in Hormone Replacement Therapy (HRT), it is primarily due to my "Root-Cause" approach. I don't just manage symptoms; I resolve the underlying biochemical and genetic imbalances that drive complex diseases. Patients value the resolution of "medical mysteries" that standard medicine often fails to address.

2. What makes you an expert on hormones?

Expertise is built through the combination of high-level research and the clinical management of thousands of complex cases. My focus has always been on the safety and efficacy of bioidentical hormones—specifically 17-beta estradiol and P4 progesterone—and how they interact with a patient's unique genetic redox profile.

3. You did endocrinology research with a US Assistant Surgeon General?

Yes. I performed endocrinological hormone research under the direction of a US Assistant Surgeon General with ties to Harvard and the NIH. This foundational research at the highest levels of government and academia shaped my evidence-based approach to endocrine health and established the rigorous standards I apply in my practice today.

4. How many years did you perform endocrinological hormone research?

I have been involved in endocrinological research and clinical application for over 30 years. This longevity allows me to see long-term trends and outcomes that younger practitioners may miss.

5. Tell me about books you’ve written on HRT?

I have authored several definitive works, including my deep dives into Natural Progesterone and the 85% Solution. My most recent work, The Tissue Eraser, specifically addresses the intersection of cytokines (like TNF-α) and hormonal health.

6. How many bestsellers have you had?

I have had multiple bestsellers. These books are designed to bridge the gap between complex medical literature and patient empowerment, providing actionable steps for those suffering from chronic inflammation and hormonal depletion.

7. At how many medical conferences have you spoken?

I have spoken at hundreds of medical conferences globally. My goal is to educate other physicians on the safety of bioidentical hormones and the necessity of checking genetic markers like MTHFR and IL-6 to prevent eclampsia, strokes, and joint destruction.

9. Do you have any special skills as a physician?

My primary skill is the ability to synthesize vast amounts of disparate data—genetics, intracellular vitamin levels, and cytokine profiles—to find the "missing link" in a patient's health.

10. What do you mean by saying you "see around corners"?

"Seeing around corners" is the ability to identify a disease state—such as a "Core Breach" or "Redox Bankruptcy"—before clinical symptoms become irreversible. By looking at a patient's homozygous genetic switches (like IL-6 or TNF-α), I can predict where their health is failing and intervene with high-dose redox protocols to "weld" the switch back to a healthy state.

12. So seeing around corners in medicine right now, what do you see coming?

The future of medicine is predictive and preventive genetics. We are moving away from "managing" chronic diseases with biologics and toward "disassembling" the inflammatory signaling complexes (like STAT3 and NF-κB) at the source using advanced liposomal delivery of SOD, Catalase, and Reduced Glutathione.

13. Have you written a book on cytokines?

Yes. It is a central theme in my recent literature because cytokines are the direct cause of the symptoms in pre-eclampsia, Crohn's, and Rheumatoid Arthritis.

14. Why do you lead the nation in 5-Star Reviews?

Because we get results. Patients come to us after seeing 10 or 20 other doctors without relief. When we finally identify their homozygous "Tissue Eraser" or "Arsonist" genes and provide the correct redox "firebreak," their lives change. That success is reflected in our 1,300+ reviews.

17. You see a wide variety of cases — how do patients know you are good at these skills?

The clinical outcomes speak for themselves. Between my published bestsellers, my peer-reviewed research, and the sheer volume of 5-star reviews from "medical mystery" cases, patients can see a clear track record of success with complex, multi-system inflammatory disorders.

18. Do you have any videos they can watch?

Yes, we have an extensive library of educational videos that break down the "Nightmare Logic" of specific cytokine pathways and explain the VARS protocol in detail.

Genetics, MTHFR & Inflammation

19. What is HOMOCYSTEINE?

Homocysteine is a toxic cardiovascular waste product that has been recognized in medical literature for over 94 years. It is essentially a "cold-eyed killer" that accumulates when there is a genetic disruption in the transsulfuration pathway—the primary biochemical system the body uses to detoxify. When this pathway is broken, you cannot manufacture enough glutathione to clear toxins like organophosphates, lead, mercury, or gadolinium, leading to systemic "Redox Bankruptcy".

20. Why is it so bad?

It is the #1 cause of death from heart attacks, strokes, and blood clots (DVTs). Furthermore, it is a primary driver of kidney failure and several types of cancer. In my forthcoming 600-page textbook on Homocysteine (Spring 2026), I detail how it stimulates the production of "thug" cytokines like IL-8 and MCP-1, which harden the arteries and destroy organ tissue through chronic inflammation.

21. No other doctor ever checks that — why do you?

Standard medicine often ignores homocysteine because they were taught there is no "cure" or easy pharmaceutical fix. In my large genetic practice, I see patients who have been to 15+ doctors with no answers. We check it because it provides the root-cause explanation for "unresolvable" inflammation. We don't just use bandages like steroids or NSAIDs; we use redox science to fix the underlying problem.

22. We do genetics — why?

Genetics is the only way to firmly diagnose the origin of a homocysteine or cytokine problem. While most doctors think MTHFR is just one or two genes, there are actually 22 distinct SNPs (variants) that can break the transsulfuration pathway. If you are homozygous on any of those 22, you cannot effectively convert homocysteine to glutathione.

23. What makes our genetic test so amazing?

I spent 20 years designing and curating this test to be the most comprehensive in the field. It looks at all 22 homocysteine SNPs, all major methylation SNPs, and crucial inflammation markers like IL-6, IL-8, and TNF-α. It also evaluates SOD 1, 2, and 3, providing a roadmap for utilizing our patented VARS technology to fill these specific genetic niches.

24. What or who do you see in our genetics practice?

I see the "medical mysteries"—people with severe, chronic inflammation or debilitating gut issues. Most have been told their issues are idiopathic, but their genetics usually reveal a clear "Redox Bankruptcy". For example, many of my Crohn's or gallbladder-loss patients are homozygous for PEMT, leading to fatty liver and bile stasis that standard tests miss.

25. Why do I say homocysteine is an MTHFR problem?

If you have a homozygous mutation in A1298C or C677T (or any of the 22 related SNPs like MTRR), you have a "bridge out" on your road to health. You cannot convert homocysteine into glutathione—the master antioxidant. This is why these patients struggle to detoxify; they are biologically incapable of producing the "cleansing" molecules they need without specific intervention.

Cytokines & The "Nightmare" Logic

26. What is the main cause of inflammation we see?

Cytokines. Plain and simple. They are the signaling molecules that drive RA, osteoarthritis, and 99% of the inflammation I see in clinical practice.

30. What is the worst cause of inflammation we see?

Homozygosity in high-expressor cytokines like IL-2R, IL-23R, IFN-γ, or TNF-α. These genetic "welded switches" cause the body to actively dismantle its own tissue, in turn causing horrifyingly painful consequences.

31. What is the worst case you’ve seen?

Severe Sarcoidosis is among the most painful and destructive. I also see "modern-day SCURVY”—severe Vitamin C deficiencies that make patients look like vampires, with bleeding gums and skin so fragile it cannot be touched without causing agony.

32. What are granulomass? / 34. What do they become?

Granulomas are walled-off, inflammatory nodules the body creates when it can't resolve a cytokine storm. They are the hallmark of Sarcoidosis and can appear in the lungs, colon, or pancreas. We use high-dose redox intervention to disassemble these nodules by quenching the superoxide "glue" that holds them together.

33. What is a cytokine? And why are they so important?

Cytokines are small signaling proteins designed to remove senescent (old/damaged) cells. They are vital for health, but when they are "jammed on" due to genetic homozygosity, they don't just kill old cells—they kill healthy brain, joint, and organ cells.

34. How do we test for these cytokines?

We have developed the MaxGen Cytokine DRP test (available mid-2026), which evaluates 35+ specific genetic SNPs for cytokines. This is the only test of its kind, allowing us to pinpoint exactly which "wrecking ball" is destroying a patient's health.

35. How do you treat high cytokines?

We use patented biotech products (we own the intellectual property and patents on these) — Reduced, Validated, Stable Glutathione (VARS), and also VARS SOD and VARS Catalase (we term the REDOX TRIAD) and it works extremely well. High-dose glutathione suppresses the production of these cytokines by quenching the intracellular oxidative stress (with the SOD) that triggers them. We have treated hundreds of patients, successfully normalizing markers like IL-8 and IL-23R snd other cytokines. Studies have shown, unequivocally that a functional validated glutathione should and does suppress all cytokines.

Hormone Replacement Therapy (HRT)

36. What is HRT?

Hormone Replacement Therapy is the restoration of Estradiol (E2), Progesterone (P4), and Testosterone to physiological levels. It is a specialized field that requires expert training to avoid the dangers of synthetic hormones. And yes, I’ve educated physicians for years on how to properly treat women with HRT.

37. What labs should a woman get before an HRT visit?

At a minimum: Serum Progesterone, Free and Total Testosterone, Serum Estradiol, TSH, Free T3, Free T4, and Thyroid Antibodies. I also strongly recommend a CBC and CMP to look for underlying infections orcytokine-driven issues.

38. What is the TEN YEAR WINDOW?

This is a critical safety rule: If a woman does not start oral 17-beta estradiolwithin 10 years of the onset of menopause (whether it caused naturally, or from trauma, or from surgery), she should generally never start oral estrogen. Or she has post-menopausal testosterone, starting oral estrogen after this window significantly increases the risk of clots, strokes, and heart attacks. However, topical estradiol remains a safe option after the 10-year mark Unless she has Factor V Leiden).

39. What is the #1 mistake doctors make with HRT?

They prescribe synthetic progestins, or conjugated equine estrogens (derived from horse urine). These are not bioidentical and carry significantly higher risks of inflammation and vascular events.

40. Natural Progesterone — its #1 benefit?

Maybe the top 2 benefits are worth mentioning because they are closely tied — natural progesterone restores "magical" sleep and eliminates 95% of hot flashes.

41. Favorite way to prescribe Progesterone?

I prefer Sublingual RDTs (Rapid Dissolve Tablets). This is the "gold standard" delivery method. I have 2,500+ women on this protocol, and I have never had a single one develop breast cancer or a blood clot while on it.

42. Favorite form of Estrogen?

17-beta Estradiol. It is exactly what the female body makes. Unlike synthetics, it is highly anti-aging and significantly reduces the risk of heart disease, diabetes, and colon cancer.

43. What do you use for vaginal dryness?

I use a compounded Testosterone vaginal cream, often mixed with Oxytocin. This combination not only restores the mucosal lining but also significantly improves libido and the ability to reach orgasm.

Conditions Treated & Logistics

44. Do we see/treat POI (Primary Ovarian Insufficiency)?

Yes. It is often driven by a severe intracellular vitamin deficiency. By aggressively treating the redox status, we see a 50–70% success rate in restarting ovulation and menses.

45. Do we see/treat POTS?

"POTS" is often a medical umbrella term for severe, undiagnosed intracellular Iron or Vitamin B deficiencies. We use specialized intracellular testing to find the deficiency and fix it, which usually resolves the symptoms.

46. Do we see/treat Fibromyalgia?

I have treated over 15,000 women with Fibromyalgia. It is a genetic disorder involving Copper Toxicity. By using natural redox options, we can get these women entirely pain-free.Also see my FACEBOOK page called END FIBROMYALGIA WITH NATURAL OPTIONS where we’ve helped 9,000+ fibro sufferers improve their lives dramatically — read the section where they say how they have changed their lives. We know it is a combination genetic issue, a copper toxicity issue, and usually several vitamin deficiencies — you deal with all those and you can improve 97-100%.

47. Do we treat gut or liver problems even advanced liver failure cases?

I regularly treat these cases and often are able to reverse liver failure cases (see my reviews) because they have been misdiagnosed and misunderstood. There’s a fairly recently discovered genetic issue called PEMT (18.8% of the USA population has it) which in most cases is the actual ROOT CAUSE of SIBO, cholecystitis, NAFLD, NASH, liver failure, hepatocellular carcinoma, Ulcerative colitis, and Crohn’s Disease. We can usually reverse the majority of these cases, once determined to be genetic, as we treat them for the underlying genetic issue. I have a 600 page textbook, called (of course) PEMT coming out on this disease this Spring/Early Summer — watch for it.

48. How can I find out if I am a fit for your practice?

Email us at info@danpursermd.com with your details of your medical problem. We are very selective, mainly because we do not want to waste your money or time or my time. but we always email back —we may have more questions for you if I am trying to figure out if we can help you. You can also call 801.796.7667 and talk to someone at the front desk or leave a message (we always call you back) so talk to anyone here — they can all hep and will.

Thank You For Reading!

- Dan Purser MD